Interactions for Caffeine

Caffeine is a central nervous system stimulant drug used as an aid to stay awake, for mental alertness due to fatigue, and as an adjunct with other drugs for pain relief. Caffeine is available alone as a nonprescription drug, in combination with other nonprescription drugs, and in prescription drug combinations for relief of pain and headache.

Common names: Cafcit, Caffedrine, Enerjets, NoDoz, Quick Pep, Snap Back, Stay Alert,Vivarin Combination drugs: Anacin, Darvon Compound, Fioricet, Fiorinal

Summary of Interactions for Caffeine

In some cases, an herb or supplement may appear in more than one category, which may seem contradictory.

✓ May be Beneficial: Depletion or Calcium interference
 Avoid: Adverse interaction Ephedra Tobacco
 Check: Other Guaraná

Side effect reduction/prevention None known Supportive interaction None known

Reduced drug absorption/bioavailability None known

Interactions with Dietary Supplements

Calcium In 205 healthy postmenopausal women, caffeine consumption (three cups of coffee per day) was associated with bone loss in women with calcium intake of less than 800 mg per day.  In a group of 980 postmenopausal women, lifetime caffeine intake equal to two cups of coffee per day was associated with decreased bone density in those who did not drink at least one glass of milk daily during most of their life.  However, in 138 healthy postmenopausal women, long-term dietary caffeine (coffee) intake was not associated with bone density.3 Until more is known, postmenopausal women should limit caffeine consumption and consume a total of approximately 1,500 mg of calcium per day (from diet and supplements).

Interactions with Herbs

Guaraná (Paullinia cupana) Guaraná is a plant with a high caffeine content. Combining caffeine drug products and guaraná increases caffeine-induced side effects. Ephedra Until 2004, many herbal weight loss and quick energy products combined caffeine or caffeine-containing herbs with ephedra. This combination may lead to dangerously increased heart rate and blood pressure and should be avoided by people with heart conditions, hypertension, diabetes, or thyroid disease.

Interactions with Foods and Other Compounds

Food Caffeine is found in coffee, tea, soft drinks, and chocolate. To reduce side effects, people taking caffeine-containing drug products should limit their intake of caffeine-containing foods/beverages. Tobacco Smoking can increase caffeine metabolism, decreasing effectiveness. Smokers who use caffeine-containing drug products may require higher amounts of caffeine to achieve effectiveness.


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