• SIBUTRAMIN 100 Tabletes  [20mg/Tab]

SIBUTRAMIN 100 Tabl  [20mg/Tab]


Sibutramine hydrochloride monohydrate Meridia (sibutramine hydrochloride) is a selective serotonin and noradrenalin re-uptake inhibitor, used for the medical management of obesity. This pharmaceutical was developed by Abbott Laboratories, who also sells it in many international markets under the brand name Reductil. Meridia is one of the more recent weight loss medications to reach the commercial drug market in the U.S., receiving Food and Drug Administration approval in 1998.This pharmaceutical is intended to be an adjunct to a reduced calorie diet, which will help increase weight loss compared to that achieved with modifying food intake alone. Meridia is not advertised as a rapid acting drug, but instead one that fosters slow, safe, and steady losses in fat mass, which are maintained long-term.


Sibutramine hydrochloride exerts a weight-loss effect through two distinct mechanisms.On the one side, it has a marked ability to suppress appetite. During some studies, patients would reduce their daily energy intake by as much as 1,300 calories while taking this drug240. In addition to its effects on caloric intake, sibutramine also stimulates metabolism and daily caloric expenditure. A single 10mg dose has been demonstrated to increase basal metabolic rate by up to 30%, an effect that is maintained for at least six hours. This thermogenic action is known to occur via the adrenergic system, mainly through the indirect support of beta 3 receptor activation. With the use of this drug, we are specifically seeing a strong increase in brown adipose tissue thermogenesis (BAT), which is accompanied by body temperature increases of .5 - 1 degree Celsius241. Elevated body temperature is a good indicator that thermogenesis is being triggered, which you may recall as one of the key things we are looking for when taking clenbuterol. To get a better idea of exactly how well Meridia works, we can take a look at some of the recent clinical studies on this agent.One such investigation was conducted at the Kansas Foundation for Clinical Pharmacology in 2001. Here, a group of 322 obese patients were given either 20mg of sibutramine or placebo once daily for 24 weeks.

By the conclusion of this study, 42% of patients in the sibutramine group lost 5% or more of their initial body weight, while 12% noticed a 10% or greater loss in body weight. Sibutramine was also associated with significant improvements in serum triglyceride and HDL cholesterol levels, which were displaying poor values at the onset of the study. Another detailed report emerged from the Department of Endocrinology for Rui-jin Hospital in China this same year, which involved giving only l0 mg per day of sibutramine to a group of 120 men and women. This investigation also faired extremely well, with patients losing an average of 15 pounds by the 24th week of use. In what seems to be a rule for all prescription weight loss medications, sibutramine is not without its potential side effects.The most common is an increase in blood pressures trait that is strong and consistent enough to contraindicate the use of this drug in patents with high blood pressure or other cardiovascular issues.

Other common side effects include dry mouth, sleeplessness, irritability, back pain, stomach upset, and constipation, all of which tend to become reduced in magnitude as the user becomes accustomed to the drug. Meridia should be discontinued immediately if any of the more serious side effects or symptoms of toxicity occur, including excitement, restlessness, loss of consciousness, confusion, agitation, weakness, shivering, clumsiness, rapid heartbeat, large pupils, vomiting, difficulty breathing, chest pains, swelling of feet, ankles or legs, fainting, disorientation, depression, high fever, eye pain, tremor, or excessive sweating. Meridia comes in three strengths, 5, 10 and 15mg per capsule. The recommended starting dosage for most patients is l0mg once daily, which is to be adjusted upwards after 4 weeks if weight loss has not been sufficiently initiated. Once established, we commonly see the effective running dosage fall between 10 and 20mg per day. Meridia is classified as a schedule IV controlled substance in the United States, which imparts some legal consequences for distribution or possession. However, that is not to say the drug is extremely difficult to obtain. Being that obesity is a ubiquitous problem in the United States, the numbers of prescriptions written for this drug every year are quite high. Searching around for a short period of time will probably uncover a number of clinics that specialize in this type of therapy quite easily, some of which will likely dispense the drug through the mail. The drug is not currently extremely popular with athletes, although it does show up in related circles from time to time. Warranted or not, most tend to look at this as more of an appetite suppressant than a serious thermogenic, and will usually opt for any number of more potent drugs first.

 

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SIBUTRAMIN 100 Tabletes [20mg/Tab]

  • $75.00

  • Ex Tax: $75.00