Human Growth Hormone (somatropin)

In the human body growth hormone is produced by the pituitary gland. It exists at especially high levels during adolescence when it promotes the growth of tissues, protein deposition and the breakdown of subcutaneous fat stores. Upon maturation endogenous levels of GH decrease, but remain present in the body at a substantially lower level. In the body the actual structure of growth hormone is a sequence of 191 amino acids. Once scientists isolated this hormone, many became convinced it would exhibit exceptional therapeutic properties. It would be especially effective in cases of pituitary deficient dwarfism, the drug perhaps restoring much linear growth if administered during adolescence.

somatropina-somatotropina

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The 1980’s brought about the first prepared drugs containing human growth hormone. The content was taken from a biological origin, the hormone being extracted from the pituitary glands of human corpses then prepared as a medical injection. This production method was short lived, however, since it was linked to the spread of a rare and fatal brain disease. Today virtually all forms of HGH are synthetically manufactured. The recombinant DNA process is very intricate; using transformed e-coli bacterial or mouse cell lines to genetically produce the hormone structure. It is highly unlikely you will cross the old biologically active item on the black market (such as Grorm), as nearly all such products have long since been discontinued.

The use of growth hormone has been increasing in popularity among athletes, due, of course, to the numerous benefits associated with use. To begin with,GH stimulates growth in most body tissues, primarily due to increases in cell number rather than size. This includes skeletal muscle tissue, and with the exception of eyes and brain all other body organs.The transport of amino acids is also increased, as is the rate of protein synthesis. All of these effect are actually mediated by IGF-1 (insulin-like growth factor), a highly anabolic hormone produced in the liver and other tissues in response to growth hormone (peak levels of IGF- 1 are noted approximately 20 hours after HGH administration). Growth hormone itself also stimulates triglyceride hydrolysis in adipose tissue, usually producing notable fat loss during treatment. GH also increases glucose output in the liver, and induces insulin resistance by blocking the activity of this hormone in target cells. A shift is seen where fats become a more primary source of fuel, further enhancing body fat loss.

Its growth promoting effect also seems to strengthen connective tissues, cartilage, and tendons. This effect should reduce the susceptibility to injury (due to heavy weight training), and increase overall lifting ability (strength). HGH is also a safe drug for the “piss-test” A/though athletic committees ban its use, there is currently no reliable method for detecting the drug during a standard urinalysis. This makes clear its attraction to (among others) professional bodybuilders, strength athletes, and Olympic competitors, who are able to use this drug straight through a tested competition. The only effective test method to date requires blood sampling, which is considered too invasive for widespread implementation (although some limited use of this test at the Olympic level is being carried out). Until a reliable method is developed that makes use of a urine sample, growth hormone will remain a highly sought after drug for the drug-tested competitive athlete.

The degree in which HGH actually works for an athlete has been the topic of a long running debate. Some claim it to be the holy grail of anabolics, capable of amazing things. Able to provide incredible muscle growth and unbelievable fat loss in a very short period of time. Since it is used primarily by serious competitors who can afford such an expensive drug, a great body of myth further surrounds HGH discussion (among those personally unfamiliar). Many will state with the utmost confidence that the incredible mass of the Olympian competitors each year is 100% due to the use of high doses of HGH. Others have crossed bodybuilding materials claiming it to be a complete waste of money, an ineffective anabolic and barely worthwhile for fat loss. With its high price tag, certainly an incredibly poor buy in the face of steroids. So we have a very wide variety of opinions regarding this drug, whom should we believe?

It is first important to understand why there the results obtained from this drug seem to vary so much. A logical factor in this regard would seem to be the price of this drug. Due to the elaborate manufacturing techniques used to produce it, it is not cheap to buy. Even a moderately dosed cycle could cost an athlete as much as $20 per daily dosage. This could be $150 per week, a figure that could go up to $300 for a formidable anabolic dose. Most are unaware or unwilling to spend so much, and instead tinker around with low dosages of the drug. Most who have used this item extensively claim it will only be effective at higher doses. Poor results would then be expected if low amounts were used, or the drug not administered daily, if you cannot commit to the full expense of an HGH cycle, you should really not be trying to use the drug.

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The average male athlete will usually need a dosage in the range of 4 to 6 I.U. per day to elicit the best results. On the low end perhaps 1 to 2 I.U.can be used daily,but this is still a considerable expense. Daily dosing is important, as HGH has a very short life span in the body. Peak blood concentrations are noted quickly (2 to 6 hours) after injection, and the hormone is cleared from the body with a half-life of only 20-30 minutes. Clearly it does not stick around very long, making stable blood levels difficult to maintain. The effects of this drug are also most pronounced when it is used for longer periods of time often many months long. Some do use it for short periods, but generally when looking for a fat loss. For this purpose a cyde of at least four weeks should be used. This compound can be administered in both an intramuscular and subcutaneous injection. “Sub-Q” injections are particularly noted for producing a localized loss of fat, requiring the user to change injection points regularly to even out the effect. A general loss of fat seems to be the one characteristic most people agree on. it
appears that the fat burning properties of this drug are more quickly apparent, and less dependent on high doses.

Other drugs also need to be used in conjunction with HGH in order to elicit the best results. Your body seems to require an increased amount of thyroid hormones, insulin, and androgens while HGH levels are elevated (HGH therapy in fact is shown to lower thyroid and insulin levels). To begin with, the addition of thyroid hormones will greatly increase the thermogenic effectiveness of a cycle. Taking either Cytomel® or Synthroid® (prescription versions of T-3 and T-4) would seem to make the most sense (the more powerful Cytomel® is usually preferred). Insulin as well is very welcome during a cycle, used most commonly in an anabolic routine as described in this book under the insulin heading. Aside from replacing lowered insulin levels, use of this hormone is important as it can increase receptor sensitivity to IGF-1, and reduce levels of IGF binding protein-1, allowing for more free circulating IGF-1 (growth hormone itself also lowers IGF binding protein levels265). Steroids as well prove very necessary for the full anabolic effect of GH to become evident. Particularly something with a notable androgenic component such as testosterone or trenbolone (if worried about estrogen) should be used. The added androgen is quite useful, as it promotes anabolism via other mechanisms untapped by GH. Steroid use may also increase free IGF-1 via a lowering of IGF binding proteins. The combination of all of these (HGH, anabolics, insulin, and T-3) proves to be the most synergistic combination, providing clearly amplified results. It is of course important to note that thyroid and insulin are particularly powerful drugs that involve a number of additional risks.

Release and action of GH and IGF-1: GHRH (growth hormone releasing hormone) and SST (somatostatin) are released by the hypothalamus to stimulate or inhibit the output of GH by the pituitary. GH has direct effects on many tissues, as well as indirect effects via the production of IGF-1. IGF-1 also causes negative feedback inhibition at the pituitary and hypothalamus. Heightened release of somatostatin affects not only the release of GH, but insulin and thyroid hormones as well.

HGH itself does not carry with it some of its own risks. The most predominantly discussed side effect would be acromegaly, or a noticeable thickening of the bones (notably the feet, forehead, hands, jaw and elbows). The durg can also enlarge vital organs such as the heart and kidney, and has been linked to hypoglycemia and diabetes (presumably due to its ability to induce insulin resistance). Theoretically, overuse of this hormone can bring about a number of conditions, some life threatening. such problems, however are extremely rare. Among the many athletes using growth hormone, we have very few documented cases of a serious problem developing. When used periodically at a moderate dosage, the athlete should have little cause for worry. Of course if there are any noticeable changes in bone structure, skin texture, or normal health and well being during use, HGH therapy should be completely halted.

In summary, the biggest mistake we can make with this drug is to get confused by the price tag. Even a relatively short cycle of this drug (and ancillaries) can cost a thousand dollars or more. We cannot jump to the conclusion that GH is therefore the most unbelievable anabolic.This hormone is simply very complex, and costly to manufacture (though it should be getting cheaper). If you were looking to achieve just a great mass gain the $1,000 would be better spent on steroids. Growth Hormone will not turn you into an overnight “freaky” monster, and it is most certainly not “the answer” Yes, it is a very effective performance enhancement tool. But it is more a tool for the competitive athlete looking for more than steroids alone can provide. There is little doubt that GH contributes considerably to the physiques and performance of many top bodybuilders and athletes. In this arena, the money spent on it is well justified, the drug obviously necessary But outside of competitive sport it is usually not.
T
he high price of human growth hormone has provided a very strong motivation for the creation of counterfeit product so one must be cautious when purchasing it. A large percentage of the GH found on the black market will in actuality be re-labeled HCG, which bears a very close resemblance. Fear not, a trip to the corner drug store provides us with a cheap and effective way to test our product. A home pregnancy test works by detecting HCG in the urine, which will be present during pregnancy. In this case we want to use it to determine if there is HCG in our growth hormone vials. A few days into your GH cycle, take a full 1 mL injection prior to bed. This would ensure a high level of HCG in the urine (if that’s what your actually taking). Upon rising, take the pregnancy test. A positive will let you know that you have been swindled.

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Both HCG and HGH are packaged in 2 separate vials, which are mixed before use (except for the new Nutropin aqueous product). One vial contains a sterile solution, the other a powder. With both the powder will not be loose but in a solid disc (lyophilized). The few fakes which are not re-labeled HCG vials will likely contain some form of loose powder, avoid.

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